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DEUTSCHE BANK AG\
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,596,600 | -159,560 | 561,859,507,000 | 8,546,176,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,756,160 | -71,297 | 553,313,331,000 | 552,784,208,000 | $315,070.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,827,457 | -213,715 | 529,123,000 | -46,058,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,041,172 | -107,454 | 575,181,000 | 14,455,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,148,626 | -410,687 | 560,726,000 | -1,298,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,559,313 | -127,278 | 562,024,000 | 74,704,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,686,591 | 647,552 | 487,320,000 | 49,151,000 | $181.39 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,039,039 | 783,218 | 438,169,000 | 141,368,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,255,821 | 236,046 | 296,801,000 | 19,300,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,019,775 | 116,703 | 277,501,000 | 15,331,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 903,072 | -36,239 | 262,170,000 | 38,660,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 939,311 | -532,686 | 223,510,000 | -98,778,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,471,997 | -7,738 | 322,288,000 | 71,597,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,479,735 | -320,786 | 250,691,000 | -79,483,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,800,521 | 403,803 | 330,174,000 | 73,255,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,396,718 | 432,709 | 256,919,000 | 97,179,000 | $183.94 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 964,009 | 116,533 | 159,740,000 | -3,599,000 | $165.70 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,296,863 | -84,362 | 249,957,000 | 15,203,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,381,225 | 41,544 | 234,754,000 | 16,416,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,339,681 | 407,204 | 218,338,000 | 78,603,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 932,477 | -59,309 | 139,735,000 | -11,052,000 | $149.85 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 991,786 | 205,898 | 150,787,000 | 49,515,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 785,888 | -388,987 | 101,272,000 | -27,196,000 | $128.86 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,174,875 | 40,805 | 128,468,000 | 44,926,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,134,070 | -194,159 | 83,542,000 | -32,288,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,328,229 | -54,153 | 115,830,000 | -3,080,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,382,382 | 187,908 | 118,910,000 | 23,967,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,194,474 | 232,843 | 94,943,000 | -5,197,000 | $79.49 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 961,631 | -206,384 | 100,140,000 | -44,083,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,168,015 | 734,846 | 144,223,000 | 126,076,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,113,698 | 680,529 | 131,380,000 | 113,233,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,174,413 | -555,422 | 139,517,000 | -54,760,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 704,183 | 271,014 | 79,084,000 | 60,937,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 759,701 | 377,511 | 71,925,000 | 44,899,000 | $94.68 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 382,190 | -50,979 | 27,026,000 | 8,879,000 | $70.71 |
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