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Avoro Capital Advisors LLC
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 4,900,000 | 0 | 188,650,000,000 | 13,279,000,000 | $38,500.00 |
| 03/31/2023 | Xenon Pharmaceuticals Inc. | XENE | 4,900,000 | 0 | 175,371,000,000 | 175,194,110,000 | $35,790.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,900,000 | 0 | 176,890,000 | 27,832,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,900,000 | -85,000 | 149,058,000 | -3,333,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,985,000 | 0 | 152,391,000 | -3,340,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 4,985,000 | 1,335,000 | 155,731,000 | 99,959,000 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,650,000 | 0 | 55,772,000 | -12,191,000 | $15.28 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,650,000 | 0 | 67,963,000 | 2,628,000 | $18.62 |
| 03/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,650,000 | 850,000 | 65,335,000 | 22,271,000 | $17.90 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,800,000 | 0 | 43,064,000 | 12,068,000 | $15.38 |
| 09/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,800,000 | 0 | 30,996,000 | -4,116,000 | $11.07 |
| 06/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,800,000 | 28,000 | 35,112,000 | 3,678,000 | $12.54 |
| 03/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 2,772,000 | 372,000 | 31,434,000 | -30,000 | $11.34 |
| 12/31/2019 | Xenon Pharmaceuticals Inc. | XENE | 2,400,000 | 0 | 31,464,000 | 9,840,000 | $13.11 |
| 09/30/2019 | Xenon Pharmaceuticals Inc. | XENE | 2,400,000 | 0 | 21,624,000 | -2,040,000 | $9.01 |
| 06/30/2019 | Xenon Pharmaceuticals Inc. | XENE | 2,400,000 | 0 | 23,664,000 | -720,000 | $9.86 |
| 03/31/2019 | Xenon Pharmaceuticals Inc. | XENE | 2,400,000 | 0 | 24,384,000 | 9,240,000 | $10.16 |
| 12/31/2018 | Xenon Pharmaceuticals Inc. | XENE | 2,400,000 | 32,782 | 15,144,000 | -16,103,000 | $6.31 |
| 09/30/2018 | Xenon Pharmaceuticals Inc. | XENE | 2,367,218 | 1,165,100 | 31,247,000 | 20,188,000 | $13.20 |
| 06/30/2018 | Xenon Pharmaceuticals Inc. | XENE | 1,202,118 | 1,202,118 | 11,059,000 | 11,059,000 | $9.20 |
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