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TOWER BRIDGE ADVISORS
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,000 | 0 | -288,780,000 | |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 288,780,000 | -760,000 | $288,780.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 289,540,000 | 7,750,000 | $289,540.00 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 281,790,000 | 20,820,000 | $281,790.00 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 260,970,000 | 260,750,400 | $260,970.00 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 1,000 | 219,600 | 219,600 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,000 | 0 | -214,890 | |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 214,890 | -21,450 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 236,340 | -35,780 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 272,120 | -290,037,880 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 290,310,000 | 290,072,050 | $290,310.00 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 237,950 | 19,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 0 | 218,950 | 17,640 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,000 | 1,000 | 201,310 | 201,310 | $201.31 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,400 | 0 | -262,440 | |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,400 | -500 | 262,440 | -213,380,560 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,900 | -700 | 213,643,000 | -100,313,000 | $73,670.00 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,600 | 0 | 313,956,000 | 4,284,000 | $87,210.00 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,600 | 3,600 | 309,672,000 | 309,672,000 | $86,020.00 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 4,600 | 365,654,000 | 365,654,000 | $79,490.00 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 578,818,000 | 99,774,000 | $125,830.00 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 479,044,000 | -88,964,000 | $104,140.00 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 568,008,000 | 25,346,000 | $123,480.00 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 542,662,000 | 193,890,000 | $117,970.00 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 546,480,000 | 29,854,000 | $118,800.00 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 516,626,000 | 81,098,000 | $112,310.00 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 435,528,000 | 110,216,000 | $94,680.00 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 325,312,000 | -16,468,000 | $70,720.00 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 341,780,000 | -6,992,000 | $74,300.00 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 4,600 | 348,772,000 | 348,772,000 | $75,820.00 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 4,600 | 368,276,000 | 368,276,000 | $80,060.00 |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 4,600 | 252,862 | 252,862 | $54.97 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -4,600 | 0 | -257,094 | |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 0 | 257,094 | -138 | $55.89 |
| 06/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,600 | 4,600 | 257,232 | 257,232 | $55.92 |
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