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UBS ASSET MANAGEMENT AMERICAS INC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,811,731 | -117,685 | 885,892,087,000 | 885,046,130,248 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,929,416 | -229,276 | 845,956,752 | -913,721,724,248 | $288.78 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,158,692 | 36,378 | 914,567,681,000 | 34,730,818,000 | $289,540.00 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,122,314 | -17,023 | 879,836,863,000 | 879,017,590,222 | $281,790.00 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,139,337 | -374,894 | 819,272,778 | 47,547,651 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,514,231 | 755,378 | 771,725,127 | -499,656,622,873 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,758,853 | 307,208 | 500,428,348,000 | 6,103,167,000 | $181,390.00 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,451,645 | 382,126 | 494,325,181,000 | 493,880,462,063 | $201,630.00 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,069,519 | -17,648 | 444,718,937 | -48,562,112 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,087,167 | 473,124 | 493,281,049 | 54,067,667 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,614,043 | 60,494 | 439,213,382 | -11,797,430 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,553,549 | 150,223 | 451,010,812 | 117,089,389 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,403,326 | 46,491 | 333,921,423 | 36,842,398 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,356,835 | -28,058 | 297,079,025 | 62,450,453 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,384,893 | -8,710 | 234,628,572 | -20,930,345 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,393,603 | 36,663 | 255,558,917 | 5,949,803 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,356,940 | -2,539 | 249,609,114 | 24,329,849 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,359,479 | 36,635 | 225,279,265 | -29,685,689 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,322,844 | -36,920 | 254,964,954 | 23,859,464 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,359,764 | 128,779 | 231,105,490 | 30,479,555 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,230,985 | -10,748 | 200,625,935 | 14,539,828 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,241,733 | 123,996 | 186,086,107 | 16,145,374 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,117,737 | -56,465 | 169,940,733 | 18,621,320 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,174,202 | -192,562 | 151,319,413 | 1,863,769 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,366,764 | 1,320,354 | 149,455,644 | 146,036,644 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 46,410 | -2,728,925 | 3,419,000 | -238,617,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,775,335 | 2,775,335 | 242,036,000 | 242,036,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,778,670 | 2,778,670 | 239,019,000 | 239,019,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,953,715 | 50,977 | 234,790,000 | -130,461,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,902,738 | 1,989,260 | 365,251,000 | 315,028,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,112,589 | 2,199,111 | 324,145,000 | 273,922,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,230,455 | 2,316,977 | 398,896,000 | 348,673,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,765,665 | 1,852,187 | 326,265,000 | 276,042,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,459,046 | 545,568 | 173,334,000 | 123,111,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,344,532 | 431,054 | 151,004,000 | 100,781,000 | $112.31 |
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