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MILLENNIUM MANAGEMENT LLC
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 174,005 | 174,005 | 4,927,822,000 | 4,927,822,000 | $28,320.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -58,421 | 0 | -1,652,000 | |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 58,421 | -65,409 | 1,652,000 | -1,093,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 123,830 | 82,995 | 2,745,000 | 1,556,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 40,835 | -49,404 | 1,189,000 | -1,777,000 | $29.12 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 90,239 | 76,651 | 2,966,000 | 2,339,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 13,588 | 13,588 | 627,000 | 627,000 | $46.14 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -233,815 | 0 | -12,074,000 | |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 233,815 | -70,450 | 12,074,000 | -1,110,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 304,265 | 173,513 | 13,184,000 | 6,191,000 | $43.33 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 130,752 | -147,176 | 6,993,000 | -2,868,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 277,928 | -68,275 | 9,861,000 | -6,670,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 346,203 | 133,095 | 16,531,000 | 9,627,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 213,108 | 169,566 | 6,904,000 | 4,732,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 43,542 | 43,542 | 2,172,000 | 2,172,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -215,902 | 0 | -9,955,000 | |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 215,902 | 160,493 | 9,955,000 | 5,682,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 55,409 | 55,409 | 4,273,000 | 4,273,000 | $77.12 |
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