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WELLINGTON MANAGEMENT GROUP LLP
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,865,628 | 142,497 | 166,114,585,000 | 34,654,265,000 | $28,320.00 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,723,131 | 574,718 | 131,460,320,000 | 131,314,723,000 | $22,970.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,148,413 | 0 | 145,597,000 | 31,457,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,148,413 | -153 | 114,140,000 | -35,735,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,148,566 | 0 | 149,875,000 | -19,358,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,148,566 | -33,787 | 169,233,000 | -69,933,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,182,353 | -1,587,362 | 239,166,000 | -133,913,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,769,715 | -83,881 | 373,079,000 | 19,159,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,853,596 | -1,023,774 | 353,920,000 | 12,593,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,877,370 | -32,838 | 341,327,000 | 64,470,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,910,208 | 43,331 | 276,857,000 | -143,863,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,866,877 | -13,744 | 420,720,000 | 141,117,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,880,621 | -81,102 | 279,603,000 | -100,569,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,961,723 | 1,248,120 | 380,172,000 | 162,651,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,713,603 | -92,637 | 217,521,000 | -121,974,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,806,240 | -1,340,703 | 339,495,000 | -209,935,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 8,146,943 | 3,827 | 549,430,000 | 173,951,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 8,143,116 | 275,737 | 375,479,000 | -231,252,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,867,379 | 220,679 | 606,731,000 | -37,350,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,646,700 | -125,574 | 644,081,000 | 8,465,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 7,772,274 | 946,674 | 635,616,000 | 245,396,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,825,600 | 55,810 | 390,220,000 | -61,663,000 | $57.17 |
| 12/29/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,825,600 | 55,810 | 390,219,552 | -61,663,448 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,769,790 | 21,303 | 451,883,000 | 104,672,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 6,748,487 | 854,891 | 347,211,000 | 3,025,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,893,596 | 11,528 | 344,186,000 | 98,727,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,882,068 | 83,737 | 245,459,000 | -60,809,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,798,331 | 5,798,331 | 306,268,000 | 306,268,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,309,050 | 5,309,050 | 222,423,000 | 222,423,000 | $41.90 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,299,078 | 31,611 | 215,141,000 | -126,824,000 | $40.60 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 5,267,467 | 290,353 | 341,965,000 | -9,370,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 4,977,114 | 652,198 | 351,335,000 | -129,335,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 4,324,916 | 1,079,278 | 480,670,000 | 174,606,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,245,638 | 1,231,158 | 306,064,000 | 80,362,000 | $94.30 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,014,480 | 351,290 | 225,702,000 | 123,665,000 | $112.04 |
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