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WADDELL & REED FINANCIAL INC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 1,613,947 | -536,823 | 72,563,000 | -49,042,000 | $44.96 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 2,150,770 | 0 | 121,605,000 | 19,551,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 2,150,770 | -15,555 | 102,054,000 | -25,673,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 2,166,325 | 14 | 127,727,000 | 25,304,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 2,166,311 | -23,826 | 102,423,000 | -29,883,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 2,190,137 | -989,941 | 132,306,000 | -58,212,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,180,078 | 19 | 190,518,000 | -13,864,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,180,059 | -182,247 | 204,382,000 | -68,536,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 3,362,306 | -135,756 | 272,918,000 | 83,813,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 3,498,062 | -334,649 | 189,105,000 | -8,586,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 3,832,711 | -697,389 | 197,691,000 | 8,922,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 4,530,100 | 0 | 188,769,000 | -10,918,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 4,530,100 | 0 | 199,687,000 | -28,178,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 4,530,100 | -12,000 | 227,865,000 | -2,420,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 4,542,100 | -598,100 | 230,285,000 | -31,197,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 5,140,200 | -10,400 | 261,482,000 | 54,427,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 5,150,600 | -592,200 | 207,055,000 | -67,623,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 5,742,800 | -70,600 | 274,678,000 | 61,675,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 5,813,400 | 5,813,400 | 213,003,000 | 213,003,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 5,949,200 | 148,100 | 138,557,000 | -96,387,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 5,801,100 | 5,801,100 | 234,944,000 | 234,944,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 5,770,300 | 5,770,300 | 357,355,000 | 357,355,000 | $61.93 |
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