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CITADEL ADVISORS LLC
> LXRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | 412,319 | 250,143 | 944,210,000 | 634,454,000 | $2,290.00 |
| 12/31/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 162,176 | 34,983 | 309,756,000 | 309,450,000 | $1,910.00 |
| 09/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 127,193 | -38,486 | 306,000 | -2,000 | $2.41 |
| 06/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 165,679 | -286,133 | 308,000 | -637,000 | $1.86 |
| 03/31/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 451,812 | 418,766 | 945,000 | 815,000 | $2.09 |
| 12/31/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 33,046 | -13,810 | 130,000 | -95,000 | $3.93 |
| 09/30/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 46,856 | 35,223 | 225,000 | 171,000 | $4.80 |
| 06/30/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 11,633 | -120,859 | 54,000 | -724,000 | $4.64 |
| 03/31/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 132,492 | 132,492 | 778,000 | 778,000 | $5.87 |
| 06/30/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -73,283 | 0 | -143,000 | |
| 03/31/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 73,283 | -245,529 | 143,000 | -1,180,000 | $1.95 |
| 12/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 318,812 | 113,844 | 1,323,000 | 706,000 | $4.15 |
| 09/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 204,968 | -337,779 | 617,000 | -2,797,000 | $3.01 |
| 06/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 542,747 | 231,120 | 3,414,000 | 1,681,000 | $6.29 |
| 03/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 311,627 | -24,195 | 1,733,000 | -497,000 | $5.56 |
| 12/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 335,822 | 322,110 | 2,230,000 | 2,084,000 | $6.64 |
| 09/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 13,712 | -90,307 | 146,000 | -1,102,000 | $10.65 |
| 06/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 104,019 | -14,202 | 1,248,000 | 235,000 | $12.00 |
| 03/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 118,221 | -50,953 | 1,013,000 | -658,000 | $8.57 |
| 12/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 169,174 | 105,068 | 1,671,000 | 883,000 | $9.88 |
| 09/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 64,106 | -46,620 | 788,000 | -1,033,000 | $12.29 |
| 06/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 110,726 | 110,726 | 1,821,000 | 1,821,000 | $16.45 |
| 03/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -18,570 | 0 | -257,000 | |
| 12/31/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 18,570 | 18,570 | 257,000 | 257,000 | $13.84 |
| 09/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -59,524 | 0 | -711,000 | |
| 06/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -59,524 | 0 | -711,000 | |
| 03/31/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 59,524 | 44,584 | 711,000 | 512,000 | $11.94 |
| 12/31/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,940 | 14,940 | 199,000 | 199,000 | $13.32 |
| 09/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -35,213 | 0 | -283,000 | |
| 06/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 35,213 | 35,213 | 283,000 | 283,000 | $8.04 |
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