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BAKER BROS. ADVISORS LP
> RARE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Ultragenyx Pharmaceutical Inc. | RARE | 783,059 | 312,085 | 36,122,512,000 | 14,302,287,000 | $46,130.00 |
| 12/31/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 470,974 | 0 | 21,820,225,000 | 21,800,722,000 | $46,330.00 |
| 09/30/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 470,974 | 0 | 19,503,000 | -8,595,000 | $41.41 |
| 06/30/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 470,974 | 26,530 | 28,098,000 | -4,178,000 | $59.66 |
| 03/31/2022 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 0 | 32,276,000 | -5,097,000 | $72.62 |
| 12/31/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 0 | 37,373,000 | -2,711,000 | $84.09 |
| 09/30/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 0 | 40,084,000 | -2,294,000 | $90.19 |
| 06/30/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 0 | 42,378,000 | -8,226,000 | $95.35 |
| 03/31/2021 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 0 | 50,604,000 | -10,920,000 | $113.86 |
| 12/31/2020 | Ultragenyx Pharmaceutical Inc. | RARE | 444,444 | 444,444 | 61,524,000 | 61,524,000 | $138.43 |
| 09/30/2017 | Ultragenyx Pharmaceutical Inc. | RARE | 0 | -25,000 | 0 | -1,553,000 | |
| 06/30/2017 | Ultragenyx Pharmaceutical Inc. | RARE | 25,000 | -25,000 | 1,553,000 | -1,836,000 | $62.12 |
| 03/31/2017 | Ultragenyx Pharmaceutical Inc. | RARE | 50,000 | 0 | 3,389,000 | -127,000 | $67.78 |
| 12/31/2016 | Ultragenyx Pharmaceutical Inc. | RARE | 50,000 | -50,000 | 3,516,000 | -3,578,000 | $70.32 |
| 09/30/2016 | Ultragenyx Pharmaceutical Inc. | RARE | 100,000 | -10,894 | 7,094,000 | 1,670,000 | $70.94 |
| 06/30/2016 | Ultragenyx Pharmaceutical Inc. | RARE | 110,894 | -13,000 | 5,424,000 | -2,420,000 | $48.91 |
| 03/31/2016 | Ultragenyx Pharmaceutical Inc. | RARE | 123,894 | 0 | 7,844,000 | -6,054,000 | $63.31 |
| 12/31/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 123,894 | 123,894 | 13,898,000 | 13,898,000 | $112.18 |
| 09/30/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 123,894 | 123,894 | 11,932,000 | 11,932,000 | $96.31 |
| 06/30/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 123,894 | 123,894 | 12,686,000 | 12,686,000 | $102.39 |
| 03/31/2015 | Ultragenyx Pharmaceutical Inc. | RARE | 148,894 | 148,894 | 9,245,000 | 9,245,000 | $62.09 |
| 12/31/2014 | Ultragenyx Pharmaceutical Inc. | RARE | 150,000 | 150,000 | 6,582,000 | 6,582,000 | $43.88 |
| 09/30/2014 | Ultragenyx Pharmaceutical Inc. | RARE | 150,000 | 150,000 | 8,490,000 | 8,490,000 | $56.60 |
| 06/30/2014 | Ultragenyx Pharmaceutical Inc. | RARE | 100,000 | 100,000 | 4,489,000 | 4,489,000 | $44.89 |
| 03/31/2014 | Ultragenyx Pharmaceutical Inc. | RARE | 100,000 | 100,000 | 4,889,000 | 4,889,000 | $48.89 |
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