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PICTET ASSET MANAGEMENT LTD
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,293,145 | -72,724 | 260,737,000 | -62,072,000 | $201.63 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,365,869 | 385,022 | 322,809,000 | 55,901,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 980,847 | -151,466 | 266,908,000 | -61,814,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,132,313 | 206,126 | 328,722,000 | 108,336,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 926,187 | -97,204 | 220,386,000 | -3,685,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,023,391 | -146,453 | 224,071,000 | 25,876,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,169,844 | 33,218 | 198,195,000 | -10,239,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,136,626 | 82,061 | 208,434,000 | 14,447,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,054,565 | 58,181 | 193,987,000 | 28,876,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 996,384 | -99,381 | 165,111,000 | -46,087,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,095,765 | -117,986 | 211,198,000 | 4,909,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,213,751 | 10,233 | 206,289,000 | 10,140,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,203,518 | 6,167 | 196,149,000 | 16,714,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,197,351 | 169,347 | 179,435,000 | 23,137,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,028,004 | -253,391 | 156,298,000 | 16,177,000 | $152.04 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,281,395 | 159,910 | 140,121,000 | 57,501,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,121,485 | 156,236 | 82,620,000 | -1,559,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 965,249 | 150,730 | 84,179,000 | 8,307,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 814,519 | 814,519 | 75,872,000 | 75,872,000 | $93.15 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 289,320 | 59,513 | 24,734,000 | 6,379,000 | $85.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 349,014 | 119,207 | 43,916,000 | 25,561,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 336,961 | 107,154 | 35,091,000 | 16,736,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 397,181 | 167,374 | 53,619,000 | 35,264,000 | $135.00 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 247,283 | 17,476 | 30,485,000 | 12,130,000 | $123.28 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 227,112 | -2,695 | 26,981,000 | 8,626,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 152,157 | -77,650 | 17,089,000 | -1,266,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 279,157 | 49,350 | 26,431,000 | 8,076,000 | $94.68 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 247,757 | 17,950 | 17,521,000 | -834,000 | $70.72 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 240,657 | 10,850 | 17,881,000 | -474,000 | $74.30 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 243,957 | 14,150 | 18,496,000 | 141,000 | $75.82 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 229,807 | 229,807 | 18,355,000 | 18,355,000 | $79.87 |
| 12/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -47,083 | 0 | -1,824,000 | |
| 09/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 47,083 | 0 | 1,824,000 | -577,200 | $38.74 |
| 06/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 47,083 | -184,648 | 2,401,200 | -8,705,700 | $51.00 |
| 03/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 231,731 | 100,724 | 11,106,900 | 6,796,800 | $47.93 |
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