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JANUS HENDERSON GROUP PLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,434,918 | 49,442 | 504,951,712,000 | 104,863,989,000 | $351,902.83 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,385,476 | -116,059 | 400,087,723,000 | 399,652,969,000 | $288,772.76 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,501,535 | -137,417 | 434,754,000 | -27,103,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,638,952 | -166,647 | 461,857,000 | -9,351,000 | $281.80 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,805,599 | -185,141 | 471,208,000 | 34,038,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,990,740 | -144,038 | 437,170,000 | 49,939,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,134,778 | -2,153,680 | 387,231,000 | -477,456,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,288,458 | -220,351 | 864,687,000 | -104,221,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,508,809 | 342,275 | 968,908,000 | -15,796,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,166,534 | 2,265,577 | 984,704,000 | 467,425,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,900,957 | -62,356 | 517,279,000 | -52,699,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,963,313 | 91,678 | 569,978,000 | 124,623,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,871,635 | -263,221 | 445,355,000 | -22,069,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,134,856 | 262,589 | 467,424,000 | 150,225,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,872,267 | 1,872,267 | 317,199,000 | 317,199,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -766,489 | 0 | -140,994,000 | |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 766,489 | -114,085 | 140,994,000 | -4,930,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 880,574 | 366,207 | 145,924,000 | 46,785,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 514,367 | -300,420 | 99,139,000 | -39,345,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 814,787 | -37,454 | 138,484,000 | -415,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 852,241 | -319,130 | 138,899,000 | -36,643,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,171,371 | 579,501 | 175,542,000 | 85,554,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 591,870 | 142,895 | 89,988,000 | 89,930,140 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 448,975 | 414,206 | 57,860 | -3,744,140 | $0.13 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 34,769 | 0 | 3,802,000 | 1,238,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 34,769 | 3,706 | 2,564,000 | -146,000 | $73.74 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,063 | 0 | 2,710,000 | 39,000 | $87.24 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,063 | 0 | 2,671,000 | 201,000 | $85.99 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,063 | 3,989 | 2,470,000 | 417,000 | $79.52 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,063 | -119,254 | 3,909,000 | -11,738,000 | $125.84 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 150,317 | 123,243 | 15,647,000 | 13,594,000 | $104.09 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 150,317 | 123,243 | 18,562,000 | 16,509,000 | $123.49 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 152,072 | 124,998 | 17,944,000 | 15,891,000 | $118.00 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 32,818 | 5,744 | 3,900,000 | 1,847,000 | $118.84 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,974 | 4,900 | 3,591,000 | 1,538,000 | $112.31 |
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