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BIOTECHNOLOGY VALUE FUND L P
> SPRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2021 | Spero Therapeutics, Inc. | SPRO | 3,411,520 | 643,242 | 54,618,435 | 941,525 | $16.01 |
| 12/31/2020 | Spero Therapeutics, Inc. | SPRO | 2,768,278 | 739,873 | 53,676,910 | 34,173,796 | $19.39 |
| 12/31/2019 | Spero Therapeutics, Inc. | SPRO | 2,028,405 | 213,259 | 19,503,114 | 8,339,966 | $9.62 |
| 12/31/2018 | Spero Therapeutics, Inc. | SPRO | 1,815,146 | 1,815,146 | 11,163,148 | 11,163,148 | $6.15 |
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