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Palo Alto Investors LP
> SAGE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Sage Therapeutics, Inc. | SAGE | 859,517 | 0 | 40,414,489,000 | 4,349,156,000 | $47,020.00 |
| 03/31/2023 | Sage Therapeutics, Inc. | SAGE | 859,517 | 3,000 | 36,065,333,000 | 3,397,775,000 | $41,960.00 |
| 12/31/2022 | Sage Therapeutics, Inc. | SAGE | 856,517 | 5,108 | 32,667,558,000 | 32,634,217,000 | $38,140.00 |
| 09/30/2022 | Sage Therapeutics, Inc. | SAGE | 851,409 | 0 | 33,341,000 | 5,840,000 | $39.16 |
| 06/30/2022 | Sage Therapeutics, Inc. | SAGE | 851,409 | -310 | 27,501,000 | -691,000 | $32.30 |
| 03/31/2022 | Sage Therapeutics, Inc. | SAGE | 851,719 | 69,989 | 28,192,000 | -5,063,000 | $33.10 |
| 12/31/2021 | Sage Therapeutics, Inc. | SAGE | 781,730 | 163,800 | 33,255,000 | 5,875,000 | $42.54 |
| 09/30/2021 | Sage Therapeutics, Inc. | SAGE | 617,930 | 17,430 | 27,380,000 | -6,734,000 | $44.31 |
| 06/30/2021 | Sage Therapeutics, Inc. | SAGE | 600,500 | 0 | 34,114,000 | -10,833,000 | $56.81 |
| 03/31/2021 | Sage Therapeutics, Inc. | SAGE | 600,500 | 10,300 | 44,947,000 | -6,111,000 | $74.85 |
| 12/31/2020 | Sage Therapeutics, Inc. | SAGE | 590,200 | 0 | 51,058,000 | 14,985,000 | $86.51 |
| 09/30/2020 | Sage Therapeutics, Inc. | SAGE | 590,200 | 15,000 | 36,073,000 | 12,156,000 | $61.12 |
| 06/30/2020 | Sage Therapeutics, Inc. | SAGE | 575,200 | -11,474 | 23,917,000 | 7,068,000 | $41.58 |
| 03/31/2020 | Sage Therapeutics, Inc. | SAGE | 586,674 | -66,920 | 16,849,000 | -30,334,000 | $28.72 |
| 12/31/2019 | Sage Therapeutics, Inc. | SAGE | 653,594 | -27,300 | 47,183,000 | -48,340,000 | $72.19 |
| 09/30/2019 | Sage Therapeutics, Inc. | SAGE | 680,894 | -114,137 | 95,523,000 | -50,039,000 | $140.29 |
| 06/30/2019 | Sage Therapeutics, Inc. | SAGE | 795,031 | -62,650 | 145,562,000 | 9,148,000 | $183.09 |
| 03/31/2019 | Sage Therapeutics, Inc. | SAGE | 857,681 | 6,704 | 136,414,000 | 54,899,000 | $159.05 |
| 12/31/2018 | Sage Therapeutics, Inc. | SAGE | 850,977 | 10,605 | 81,515,000 | -37,188,000 | $95.79 |
| 09/30/2018 | Sage Therapeutics, Inc. | SAGE | 840,372 | 7,836 | 118,703,000 | -11,614,000 | $141.25 |
| 06/30/2018 | Sage Therapeutics, Inc. | SAGE | 832,536 | 14,205 | 130,317,000 | -1,492,000 | $156.53 |
| 03/31/2018 | Sage Therapeutics, Inc. | SAGE | 818,331 | 7,525 | 131,809,000 | -1,739,000 | $161.07 |
| 12/31/2017 | Sage Therapeutics, Inc. | SAGE | 810,806 | 23,555 | 133,548,000 | 84,502,000 | $164.71 |
| 09/30/2017 | Sage Therapeutics, Inc. | SAGE | 787,251 | -245,774 | 49,046,000 | -33,224,000 | $62.30 |
| 06/30/2017 | Sage Therapeutics, Inc. | SAGE | 1,033,025 | -68,926 | 82,270,000 | 3,954,000 | $79.64 |
| 03/31/2017 | Sage Therapeutics, Inc. | SAGE | 1,101,951 | 92,021 | 78,316,000 | 26,749,000 | $71.07 |
| 12/31/2016 | Sage Therapeutics, Inc. | SAGE | 1,009,930 | 107,879 | 51,567,000 | 10,028,000 | $51.06 |
| 09/30/2016 | Sage Therapeutics, Inc. | SAGE | 902,051 | 484,173 | 41,539,000 | 28,948,000 | $46.05 |
| 06/30/2016 | Sage Therapeutics, Inc. | SAGE | 417,878 | 417,878 | 12,591,000 | 12,591,000 | $30.13 |
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