| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/17/2023 | Ives Jeffrey L. | Director | Sale | Common Stock | 39.1k | $6.48 | $253.7k | | 08/17/2023 |
| 08/17/2023 | Ives Jeffrey L. | Director | Sale | Common Stock | 2.8k | $6.66 | $18.6k | | 08/17/2023 |
| 08/17/2023 | Ives Jeffrey L. | Director | Exercise | Stock Option (right to buy) | 39.1k | $0.72 | $28.2k | | 08/17/2023 |
| 08/17/2023 | Ives Jeffrey L. | Director | Exercise | Stock Option (right to buy) | 2.8k | $1.19 | $3.3k | | 08/17/2023 |
| 06/06/2023 | Stalfort John A III | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 06/06/2023 | Stoppel Laura | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 06/06/2023 | Porter Derrell | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 06/06/2023 | Ives Jeffrey L. | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 06/06/2023 | Fountain Nathan B | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 06/06/2023 | Drapkin Kimberlee C | Director | Grant | Stock Option (right to buy) | 25k | $5.20 | $130k | | 06/06/2023 |
| 01/04/2023 | Porter Derrell | Director | Grant | Stock Option Grant (right to buy) | 50k | $5.46 | $273k | | 01/04/2023 |
| 12/29/2022 | Zuga Matt | CFO and Chief Business Officer | Exercise | Stock Option (right to buy) | 50k | $1.19 | $59.5k | | 12/29/2022 |
| 09/06/2022 | Meisner Derek M | Chief Legal Office & Corp Sec | Grant | Employee Stock Option (right to buy) | 225k | $6.08 | $1.4M | | 09/06/2022 |
| 06/15/2022 | Drapkin Kimberlee C | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 06/15/2022 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Grant | Stock Option (Right to Buy) | 25k | $3.59 | $89.8k | See footnotes | 06/15/2022 |
| 06/15/2022 | Fountain Nathan B | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 06/15/2022 | Stoppel Laura | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 06/15/2022 | Ives Jeffrey L. | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 06/15/2022 | Stalfort John A III | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 06/15/2022 | Sevigny Jeffrey | Director | Grant | Stock Option (right to buy) | 25k | $3.59 | $89.8k | | 06/15/2022 |
| 04/01/2022 | Drapkin Kimberlee C | Director | Grant | Stock Option Grant (right to buy) | 50k | $4.01 | $200.5k | | 04/01/2022 |
| 01/19/2022 | Zuga Matt | CFO and Chief Business Officer | Grant | Employee Stock Option (right to buy) | 150k | $5.19 | $778.5k | | 01/19/2022 |
| 01/19/2022 | Siemers Eric | Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 90k | $5.19 | $467.1k | | 01/19/2022 |
| 01/19/2022 | OConnell Daniel Joseph | President and CEO | Grant | Employee Stock Option (right to buy) | 455k | $5.19 | $2.4M | | 01/19/2022 |
| 01/19/2022 | Barton Russell | COO | Grant | Employee Stock Option (right to buy) | 135k | $5.19 | $700.6k | | 01/19/2022 |
| 11/30/2021 | OConnell Daniel Joseph | President and CEO | Exercise | Stock Option (Right to Buy) | 1.1k | $4.47 | $5k | | 11/30/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Series B Preferred Stock | 588.8k | $0.00 | $0 | See footnotes | 07/06/2021 |
| 07/06/2021 | Sands Capital Ventures Discovery Fund III, L.P. | 10% Owner | Conversion | Series B Preferred Stock | 1.8M | $0.00 | $0 | | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Common Stock | 6.1M | $0.00 | $0 | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Purchase | Common Stock | 1.8M | $16.00 | $28.1M | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Common Stock | 1.2M | $0.00 | $0 | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Purchase | Common Stock | 115.7k | $16.00 | $1.9M | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Common Stock | 588.8k | $0.00 | $0 | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Series B Preferred Stock | 6.1M | $0.00 | $0 | See footnotes | 07/06/2021 |
| 07/06/2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Conversion | Series B Preferred Stock | 1.2M | $0.00 | $0 | See footnotes | 07/06/2021 |
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