| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/08/2006 | WHITMER WILLIAM E | Director | Grant | Stock Option (Right to Buy) | 10k | $2.65 | $26.5k | | 08/08/2006 |
| 08/08/2006 | TOBOROFF LEONARD | Director | Grant | Stock Option (Right to Buy) | 10k | $2.65 | $26.5k | | 08/08/2006 |
| 06/19/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 6.7k | $2.25 | $15.1k | | 06/19/2006 |
| 06/19/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 6.8k | $2.25 | $15.3k | | 06/19/2006 |
| 06/19/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 11.5k | $2.25 | $25.9k | | 06/19/2006 |
| 06/19/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 71.1k | $2.25 | $159.9k | | 06/19/2006 |
| 06/19/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 9.8k | $2.25 | $22.2k | | 06/19/2006 |
| 02/15/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 159.4k | $2.54 | $404.9k | | 02/15/2006 |
| 02/06/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 9.7k | $2.50 | $24.2k | | 02/06/2006 |
| 02/02/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 18.3k | $2.43 | $44.6k | | 02/02/2006 |
| 02/01/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 2k | $2.35 | $4.7k | | 01/31/2006 |
| 01/31/2006 | STEEL PARTNERS II LP | 10% Owner | Purchase | Common Stock, $.01 par value | 1.6k | $2.28 | $3.7k | | 01/31/2006 |
| 11/12/2004 | WELDON THOMAS D | Chairman | Gift | Common Stock | 30k | $0.00 | $0 | | 11/23/2004 |
| 10/18/2004 | JANA PARTNERS LLC | 10% Owner | Disposition | Common Stock | 803.2k | $1.45 | $1.2M | | 10/19/2004 |
| 10/18/2004 | JANA PARTNERS LLC | 10% Owner | Sale | Common Stock | 803.2k | $1.45 | $1.2M | | 10/18/2004 |
| 07/15/2004 | WOOD ROBERT N JR | V.P. of Sales and Marketing | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 07/15/2004 | SMITH SUSAN D | V.P., Human Resources | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 07/15/2004 | SARDA SUBHASH C | Acting CFO | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 07/15/2004 | NOVAK ALFRED J | President and C.E.O. | Grant | Incentive Stock Option (right to buy) | 200k | $2.90 | $580k | | 07/16/2004 |
| 07/15/2004 | LOWE ADAM G | V.P. of Quality Assurance | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 07/15/2004 | HALL DANIEL G | VP & General Counsel | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 07/15/2004 | GREEN ANDREW M | VP, Regulatory & Clinical Affa | Grant | Incentive Stock Option (right to buy) | 75k | $2.90 | $217.5k | | 07/16/2004 |
| 06/14/2004 | WHITMER WILLIAM E | Director | Grant | Incentive Stock Option (right to buy) | 8k | $2.96 | $23.7k | | 06/15/2004 |
| 06/14/2004 | WELDON THOMAS D | Chairman | Grant | Incentive Stock Option (right to buy) | 12k | $2.96 | $35.5k | | 06/15/2004 |
| 06/14/2004 | SHAPIRO STEPHEN I | Director | Grant | Incentive Stock Option (right to buy) | 8k | $2.96 | $23.7k | | 06/15/2004 |
| 06/14/2004 | LINDSTROM JUDY | Director | Grant | Incentive Stock Option (right to buy) | 8k | $2.96 | $23.7k | | 06/15/2004 |
| 06/14/2004 | LARSEN CHARLES E | Director | Grant | Incentive Stock Option (right to buy) | 8k | $2.96 | $23.7k | | 06/15/2004 |
| 06/14/2004 | HOLMES J STEPHEN | Director | Grant | Incentive Stock Option (right to buy) | 8k | $2.96 | $23.7k | | 06/15/2004 |
| 02/11/2004 | SARDA SUBHASH C | Acting CFO | Grant | Incentive Stock Option (right to buy) | 16.3k | $5.20 | $84.8k | | 03/30/2004 |
| 08/12/2003 | SARDA SUBHASH C | Acting CFO | Grant | Incentive Stock Option (right to buy) | 8.7k | $4.50 | $39.2k | | 08/28/2003 |
| 06/30/2003 | DURUS CAPITAL MANAGEMENT | 10% Owner | Sale | | 14k | $5.98 | $83.7k | See Footnote | 03/05/2003 |
| 06/30/2003 | DURUS LIFE SCIENCES MASTER FUND LTD | 10% Owner | Sale | Common Stock | 50k | $6.00 | $300k | | 06/30/2003 |
| 06/30/2003 | DURUS LIFE SCIENCES MASTER FUND LTD | 10% Owner | Sale | Common Stock | 76.4k | $6.01 | $459.5k | | 03/06/2003 |
| 06/30/2003 | DURUS CAPITAL MANAGEMENT | 10% Owner | Sale | | 76.4k | $5.98 | $456.8k | See Footnote | 03/05/2003 |
| 06/30/2003 | DURUS CAPITAL MANAGEMENT | 10% Owner | Sale | | 50k | $5.95 | $297.5k | See Footnote | 03/05/2003 |
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