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JANUS HENDERSON INVESTORS US LLC
> AMGN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2017 | AMGEN INC | AMGN | 0 | -6,333,164 | 0 | -1,039,061,000 | |
| 06/30/2017 | AMGEN INC | AMGN | 0 | -6,333,164 | 0 | -1,039,061,000 | |
| 03/31/2017 | AMGEN INC | AMGN | 6,333,164 | -603,964 | 1,039,061,000 | 24,700,000 | $164.07 |
| 12/31/2016 | AMGEN INC | AMGN | 6,937,128 | -9,476 | 1,014,361,000 | -144,405,000 | $146.22 |
| 09/30/2016 | AMGEN INC | AMGN | 6,946,604 | -619,302 | 1,158,766,000 | 7,646,000 | $166.81 |
| 06/30/2016 | AMGEN INC | AMGN | 7,565,906 | 7,565,906 | 1,151,120,000 | 1,151,120,000 | $152.15 |
| 03/31/2016 | AMGEN INC | AMGN | 9,656,023 | -406,602 | 1,447,823,000 | -185,613,000 | $149.94 |
| 12/31/2015 | AMGEN INC | AMGN | 10,062,625 | 6,363,169 | 1,633,436,000 | 1,307,394,000 | $162.33 |
| 09/30/2015 | AMGEN INC | AMGN | 8,462,298 | 4,762,842 | 1,170,520,000 | 844,478,000 | $138.32 |
| 06/30/2015 | AMGEN INC | AMGN | 7,486,663 | 3,787,207 | 1,149,273,000 | 823,231,000 | $153.51 |
| 03/31/2015 | AMGEN INC | AMGN | 6,409,178 | 2,709,722 | 1,024,576,000 | 698,534,000 | $159.86 |
| 12/31/2014 | AMGEN INC | AMGN | 3,883,702 | 184,246 | 618,694,000 | 299,801,000 | $159.31 |
| 09/30/2014 | AMGEN INC | AMGN | 120,934 | -3,578,522 | 16,986,000 | -301,907,000 | $140.46 |
| 06/30/2014 | AMGEN INC | AMGN | 501,607 | -3,197,849 | 59,375,000 | -259,518,000 | $118.37 |
| 03/31/2014 | AMGEN INC | AMGN | 1,818,265 | -3,369,326 | 224,265,000 | -287,543,000 | $123.34 |
| 12/31/2013 | AMGEN INC | AMGN | 3,523,200 | -1,021,549 | 402,209,000 | -106,530,000 | $114.16 |
| 09/30/2013 | AMGEN INC | AMGN | 4,544,749 | -642,842 | 508,739,000 | -3,069,000 | $111.94 |
| 06/30/2013 | AMGEN INC | AMGN | 5,187,591 | -303,165 | 511,808,000 | -51,049,000 | $98.66 |
| 03/31/2013 | AMGEN INC | AMGN | 5,490,756 | 1,791,300 | 562,857,000 | 243,964,000 | $102.51 |
| 12/31/2012 | AMGEN INC | AMGN | 3,699,456 | 1,981,100 | 318,893,000 | 174,870,000 | $86.20 |
| 09/30/2012 | AMGEN INC | AMGN | 1,718,356 | 569,022 | 144,023,000 | 60,076,000 | $83.81 |
| 06/30/2012 | AMGEN INC | AMGN | 1,149,334 | 967,800 | 83,947,000 | 71,605,000 | $73.04 |
| 03/31/2012 | AMGEN INC | AMGN | 181,534 | -247,192 | 12,342,000 | -11,216,000 | $67.99 |
| 12/31/2011 | AMGEN INC | AMGN | 206,726 | -222,000 | 13,274,000 | -10,284,000 | $64.21 |
| 09/30/2011 | AMGEN INC | AMGN | 430,426 | -260,000 | 23,652,000 | -16,634,000 | $54.95 |
| 06/30/2011 | AMGEN INC | AMGN | 690,426 | 409,426 | 40,286,000 | 25,267,000 | $58.35 |
| 03/31/2011 | AMGEN INC | AMGN | 281,500 | -139,600 | 15,046,000 | -8,072,000 | $53.45 |
| 12/31/2010 | AMGEN INC | AMGN | 421,100 | -620,360 | 23,118,000 | -34,277,000 | $54.90 |
| 09/30/2010 | AMGEN INC | AMGN | 1,041,460 | -835,933 | 57,395,000 | -41,356,000 | $55.11 |
| 06/30/2010 | AMGEN INC | AMGN | 1,877,393 | 101,734 | 98,751,000 | -7,362,000 | $52.60 |
| 03/31/2010 | AMGEN INC | AMGN | 1,775,659 | -474,410 | 106,113,000 | -21,174,000 | $59.76 |
| 12/31/2009 | AMGEN INC | AMGN | 2,199,769 | -4,586,094 | 124,441,000 | -284,271,000 | $56.57 |
| 09/30/2009 | AMGEN INC | AMGN | 6,785,863 | -1,485,628 | 408,712,000 | -29,181,000 | $60.23 |
| 06/30/2009 | AMGEN INC | AMGN | 8,271,491 | 741,226 | 437,893,000 | 3,021,000 | $52.94 |
| 03/31/2009 | AMGEN INC | AMGN | 8,613,088 | 1,082,823 | 426,520,000 | -8,352,000 | $49.52 |
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