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CITADEL ADVISORS LLC
> ONCE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2019 | Spark Therapeutics, Inc. | ONCE | 654,852 | 22,676 | 63,507,000 | -1,215,000 | $96.98 |
| 06/30/2019 | Spark Therapeutics, Inc. | ONCE | 632,176 | 22,469 | 64,722,000 | -4,711,000 | $102.38 |
| 03/31/2019 | Spark Therapeutics, Inc. | ONCE | 609,707 | 566,607 | 69,433,000 | 67,746,000 | $113.88 |
| 12/31/2018 | Spark Therapeutics, Inc. | ONCE | 43,100 | -30,301 | 1,687,000 | -2,317,000 | $39.14 |
| 09/30/2018 | Spark Therapeutics, Inc. | ONCE | 73,401 | -30,825 | 4,004,000 | -4,621,000 | $54.55 |
| 06/30/2018 | Spark Therapeutics, Inc. | ONCE | 104,226 | 100,487 | 8,625,000 | 8,376,000 | $82.75 |
| 03/31/2018 | Spark Therapeutics, Inc. | ONCE | 3,739 | -24,445 | 249,000 | -1,200,000 | $66.60 |
| 12/31/2017 | Spark Therapeutics, Inc. | ONCE | 28,184 | 14,561 | 1,449,000 | 234,000 | $51.41 |
| 09/30/2017 | Spark Therapeutics, Inc. | ONCE | 13,623 | -867,281 | 1,215,000 | -51,411,000 | $89.19 |
| 06/30/2017 | Spark Therapeutics, Inc. | ONCE | 880,904 | 787,334 | 52,626,000 | 47,635,000 | $59.74 |
| 03/31/2017 | Spark Therapeutics, Inc. | ONCE | 93,570 | -298,873 | 4,991,000 | -14,592,000 | $53.34 |
| 12/31/2016 | Spark Therapeutics, Inc. | ONCE | 392,443 | 392,443 | 19,583,000 | 19,583,000 | $49.90 |
| 09/30/2016 | Spark Therapeutics, Inc. | ONCE | 0 | -12,728 | 0 | -651,000 | |
| 06/30/2016 | Spark Therapeutics, Inc. | ONCE | 12,728 | 12,728 | 651,000 | 651,000 | $51.15 |
| 03/31/2016 | Spark Therapeutics, Inc. | ONCE | 0 | -3,896 | 0 | -177,000 | |
| 12/31/2015 | Spark Therapeutics, Inc. | ONCE | 3,896 | 3,896 | 177,000 | 177,000 | $45.43 |
| 09/30/2015 | Spark Therapeutics, Inc. | ONCE | 0 | -4,253 | 0 | -256,000 | |
| 06/30/2015 | Spark Therapeutics, Inc. | ONCE | 4,253 | 1,885 | 256,000 | 72,000 | $60.19 |
| 03/31/2015 | Spark Therapeutics, Inc. | ONCE | 2,368 | 2,368 | 184,000 | 184,000 | $77.70 |
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