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BAKER BROS. ADVISORS LP
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 1,985,603 | -33,300 | 764,000 | -102,000 | $0.38 |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 2,018,903 | 0 | 866,000 | -265,000 | $0.43 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 2,018,903 | -227,856 | 1,131,000 | -464,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 2,246,759 | -43,909 | 1,595,000 | 862,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 2,290,668 | 2,290,668 | 733,000 | 733,000 | $0.32 |
| 09/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 2,290,668 | 0 | 2,588,000 | -963,000 | $1.13 |
| 06/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 2,290,668 | -43,798 | 3,551,000 | -1,258,000 | $1.55 |
| 03/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 2,334,466 | 0 | 4,809,000 | -2,171,000 | $2.06 |
| 12/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,334,466 | 0 | 6,980,000 | 163,000 | $2.99 |
| 09/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,334,466 | -80,000 | 6,817,000 | -10,084,000 | $2.92 |
| 06/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,414,466 | 0 | 16,901,000 | -845,000 | $7.00 |
| 03/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,414,466 | -4,269 | 17,746,000 | -442,000 | $7.35 |
| 12/31/2006 | METABASIS THERAPEUTICS INC | MBRX | 2,418,735 | 0 | 18,188,000 | 4,595,000 | $7.52 |
| 09/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 2,418,735 | 230,381 | 13,593,000 | -3,104,000 | $5.62 |
| 06/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 2,188,354 | 0 | 16,697,000 | -3,195,000 | $7.63 |
| 03/31/2006 | METABASIS THERAPEUTICS INC | MBRX | 2,188,354 | 1,100,000 | 19,892,000 | 11,185,000 | $9.09 |
| 12/31/2005 | METABASIS THERAPEUTICS INC | MBRX | 1,088,354 | 590,644 | 8,707,000 | 5,805,000 | $8.00 |
| 09/30/2005 | METABASIS THERAPEUTICS INC | MBRX | 497,710 | -20,000 | 2,902,000 | 1,271,000 | $5.83 |
| 06/30/2005 | METABASIS THERAPEUTICS INC | MBRX | 517,710 | 0 | 1,631,000 | -129,000 | $3.15 |
| 03/31/2005 | METABASIS THERAPEUTICS INC | MBRX | 517,710 | 185,208 | 1,760,000 | -651,000 | $3.40 |
| 12/31/2004 | METABASIS THERAPEUTICS INC | MBRX | 332,502 | 332,502 | 2,411,000 | 2,411,000 | $7.25 |
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