| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/08/2023 | Evelo Biosciences, Inc. | EVLO | Grant | Stock Option (Right to Buy) | 20k | $0.11 | $2.2k | | 06/08/2023 |
| 05/11/2023 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 2k | $0.00 | $0 | | 05/11/2023 |
| 05/11/2023 | Lantheus Holdings, Inc. | LNTH | Grant | Stock Option (right to buy) | 3.8k | $99.38 | $377.4k | | 05/11/2023 |
| 11/21/2022 | AERIE PHARMACEUTICALS INC | AERI | Disposition | Stock Option (right to buy) | 16.9k | $6.11 | $103k | | 11/21/2022 |
| 11/21/2022 | AERIE PHARMACEUTICALS INC | AERI | Disposition | Stock Option (right to buy) | 7.8k | $13.27 | $103.5k | | 11/21/2022 |
| 11/21/2022 | AERIE PHARMACEUTICALS INC | AERI | Disposition | Common Stock | 16.1k | $15.25 | $245.4k | | 11/21/2022 |
| 09/06/2022 | Lantheus Holdings, Inc. | LNTH | Sale | Common Stock | 4.3k | $78.50 | $337.6k | | 09/06/2022 |
| 06/09/2022 | AERIE PHARMACEUTICALS INC | AERI | Grant | Common Stock | 6.2k | $0.00 | $0 | | 06/09/2022 |
| 06/09/2022 | AERIE PHARMACEUTICALS INC | AERI | Grant | Stock Option (right to buy) | 16.9k | $6.11 | $103k | | 06/09/2022 |
| 06/09/2022 | Evelo Biosciences, Inc. | EVLO | Grant | Stock Option (Right to Buy) | 20k | $2.60 | $52k | | 06/09/2022 |
| 06/01/2022 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 21.6k | $0.00 | $0 | | 06/01/2022 |
| 05/11/2022 | Lantheus Holdings, Inc. | LNTH | Sale | Common Stock | 3k | $57.84 | $172.4k | | 05/11/2022 |
| 05/06/2022 | Lantheus Holdings, Inc. | LNTH | Grant | Stock Option (right to buy) | 4.1k | $64.20 | $261.2k | | 05/06/2022 |
| 05/06/2022 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 2.2k | $0.00 | $0 | | 05/06/2022 |
| 05/06/2022 | Lantheus Holdings, Inc. | LNTH | Grant | Stock Option (right to buy) | 3.6k | $64.20 | $232.1k | | 05/06/2022 |
| 03/14/2022 | IRONWOOD PHARMACEUTICALS INC | IRWD | Sale | Class A Common Stock | 20k | $11.67 | $233.4k | | 03/14/2022 |
| 12/14/2021 | IRONWOOD PHARMACEUTICALS INC | IRWD | Sale | Common Stock | 10k | $11.02 | $110.2k | | 12/14/2021 |
| 06/02/2021 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 22.8k | $0.00 | $0 | | 06/02/2021 |
| 05/10/2021 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 8.5k | $0.00 | $0 | | 05/10/2021 |
| 04/20/2021 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 2.5k | $0.00 | $0 | | 04/20/2021 |
| 04/09/2021 | Evelo Biosciences, Inc. | EVLO | Grant | Stock Option (Right to Buy) | 31.4k | $10.04 | $315.1k | | 04/09/2021 |
| 04/09/2021 | Lantheus Holdings, Inc. | LNTH | Sale | Common Stock | 2.8k | $21.22 | $59.4k | | 04/09/2021 |
| 10/01/2020 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 1.3k | $0.00 | $0 | | 10/01/2020 |
| 09/08/2020 | IRONWOOD PHARMACEUTICALS INC | IRWD | Sale | Class A Common Stock | 8k | $9.77 | $77.7k | | 09/08/2020 |
| 08/10/2020 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 749 | $0.00 | $0 | | 08/10/2020 |
| 06/11/2020 | AERIE PHARMACEUTICALS INC | AERI | Grant | Common Stock | 1.8k | $0.00 | $0 | | 06/11/2020 |
| 06/11/2020 | AERIE PHARMACEUTICALS INC | AERI | Grant | Stock Option (right to buy) | 7.8k | $13.27 | $103.5k | | 06/11/2020 |
| 06/03/2020 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 21.7k | $0.00 | $0 | | 06/03/2020 |
| 05/13/2020 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 64.1k | $1.05 | $67.3k | | 05/13/2020 |
| 03/03/2020 | Lantheus Holdings, Inc. | LNTH | Grant | Common Stock | 8.1k | $0.00 | $0 | | 03/03/2020 |
| 02/27/2020 | Lantheus Holdings, Inc. | LNTH | Sale | Common Stock | 1.8k | $15.86 | $27.8k | | 02/27/2020 |
| 06/05/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Sale | Class A Common Stock | 1.5k | $11.26 | $16.9k | | 06/05/2019 |
| 05/29/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 22.7k | $0.00 | $0 | | 05/29/2019 |
| 05/23/2019 | AERIE PHARMACEUTICALS INC | AERI | Grant | Common Stock | 1.8k | $0.00 | $0 | | 05/23/2019 |
| 05/23/2019 | AERIE PHARMACEUTICALS INC | AERI | Grant | Stock Option (right to buy) | 7.8k | $39.44 | $307.6k | | 05/23/2019 |
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