| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/09/2023 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 174.5k | $1.38 | $240.8k | By Opaleye, L.P. | 03/09/2023 |
| 03/01/2023 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 4.8k | $1.52 | $7.3k | | 02/28/2023 |
| 02/28/2023 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 200 | $1.52 | $304 | | 02/28/2023 |
| 02/01/2023 | THEUER CHARLES | President and CEO | Grant | Employee Stock Option (Right to Buy) | 332k | $1.70 | $564.4k | | 02/01/2023 |
| 02/01/2023 | Brown Scott B. | CFO | Grant | Employee Stock Option (Right to Buy) | 144k | $1.70 | $244.8k | | 02/01/2023 |
| 02/01/2023 | Adams Bonne J. | COO | Grant | Employee Stock Option (Right to Buy) | 99k | $1.70 | $168.3k | | 02/01/2023 |
| 01/18/2023 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 6.8k | $1.62 | $11k | | 01/18/2023 |
| 12/29/2022 | Brown Scott B. | CFO | Purchase | Common Stock | 3.5k | $1.49 | $5.2k | | 12/29/2022 |
| 12/21/2022 | LARUE WILLIAM R | Director | Sale | Common Stock | 120 | $1.26 | $150.6 | | 12/21/2022 |
| 12/14/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 23k | $1.29 | $29.8k | | 12/14/2022 |
| 12/14/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 140k | $1.26 | $175.8k | By Opaleye, L.P. | 12/14/2022 |
| 12/14/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 27.5k | $1.24 | $34.1k | By Managed Account. | 12/14/2022 |
| 12/06/2022 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.01 per share | 1.5k | $1.44 | $2.2k | By Opaleye, L.P. | 12/06/2022 |
| 12/06/2022 | Opaleye Management Inc. | 10% Owner | Exercise (in-the-money or at-the-money) | Prefunded Warrants | 221.5k | $0.01 | $2.2k | By Opaleye, L.P. | 12/06/2022 |
| 11/18/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 13.9k | $1.41 | $19.6k | | 11/18/2022 |
| 10/07/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 5k | $1.77 | $8.8k | | 10/07/2022 |
| 10/03/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 5k | $1.67 | $8.4k | | 10/03/2022 |
| 09/29/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 9.4k | $1.74 | $16.4k | By Managed Account. | 09/29/2022 |
| 09/27/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 1.7k | $1.69 | $2.9k | By Managed Account. | 09/27/2022 |
| 09/22/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 5k | $1.76 | $8.8k | | 09/22/2022 |
| 09/22/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 3.4k | $1.73 | $5.9k | By Opaleye, L.P. | 09/22/2022 |
| 09/22/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 13.9k | $1.73 | $24k | By Managed Account. | 09/22/2022 |
| 09/20/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 10k | $1.85 | $18.5k | By Managed Account. | 09/20/2022 |
| 09/19/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 5k | $1.87 | $9.4k | By Managed Account. | 09/19/2022 |
| 09/12/2022 | Brown Scott B. | CFO | Purchase | Common Stock | 2.5k | $2.02 | $5k | | 09/12/2022 |
| 07/26/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 2.3k | $1.72 | $3.9k | By Managed Account. | 07/26/2022 |
| 07/22/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 4.5k | $1.85 | $8.3k | | 07/22/2022 |
| 07/15/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 11.8k | $1.78 | $21.1k | By Managed Account. | 07/15/2022 |
| 07/14/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 7.2k | $1.81 | $13k | By Managed Account. | 07/14/2022 |
| 07/13/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 3k | $1.84 | $5.5k | | 07/12/2022 |
| 07/12/2022 | THEUER CHARLES | President and CEO | Purchase | Common Stock | 3k | $1.87 | $5.6k | | 07/12/2022 |
| 06/24/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 11.4k | $1.39 | $15.9k | By Managed Account. | 06/24/2022 |
| 06/21/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 842k | $1.31 | $1.1M | By Opaleye, L.P. | 06/21/2022 |
| 06/14/2022 | LARUE WILLIAM R | Director | Grant | Director Stock Option (Right to Buy) | 15.8k | $1.30 | $20.5k | | 06/14/2022 |
| 06/14/2022 | MATTINGLY MARTIN A | Director | Grant | Director Stock Option (Right to Buy) | 15.8k | $1.30 | $20.5k | | 06/14/2022 |
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